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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Pharmacol Biochem Behav. 2016 Sep 30;150-151:76–86. doi: 10.1016/j.pbb.2016.09.008

Figure 3. Extinction of Cocaine Self-administration.

Figure 3

Number of “cocaine” (●) and candy (○) reinforcers earned each session (maximum = 10) during the extinction phase when saline was substituted for cocaine. These data represent week 21 to 29 post-vaccination. Additional boosts of dAd5GNE or vehicle were administered at week 19 and 34 so are not depicted in the Figure. Panels A and B show the 2 control monkeys, panels C–F show the 4 vaccinated monkeys. B = baseline and refers to the number of cocaine and candy reinforcers earned during week 20 of the cocaine self-administration phase (see Figure 2; week −1 was used for monkey V2, the one monkey who shifted preference from cocaine to candy). The dashed line indicates when extinction criteria were met for each monkey (defined as responding for ≤2 “cocaine choices” for 3 consecutive sessions). Typically there were 4–5 sessions per week; each data point (other than B) represents a single session.