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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Pharmacol Biochem Behav. 2016 Sep 30;150-151:76–86. doi: 10.1016/j.pbb.2016.09.008

Figure 4. Reacquisition of Cocaine Self-administration in Control Monkeys.

Figure 4

Number of number of cocaine (●) and candy (○) reinforcers earned each session (maximum = 10) during the reacquisition phase when cocaine was available again in the 2 control monkeys C1 and C2. B = baseline and refers to the number of cocaine and candy reinforcers earned during week 20 of the cocaine self-administration phase (see Figure 2 A and B). Gray arrows indicate when dAd5GNE or vehicle was administered. The x-axis corresponds to weeks post-vaccination and indicates the number of sessions needed to reacquire cocaine self-administration for each monkey. For monkey C2, the VAP became blocked in week 35 and sessions were suspended (indicated by the break on the x-axis). Sessions resumed in week 41; the candy lever was locked for a single session (indicated by the gray circle) and control monkey C2 immediately returned to cocaine self-administration. Typically there were 4–5 sessions per week; each data point (other than B) represents a single session.