Table 1.
Subject | Group | Injection Order |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ||
101 | Ascending | Ket 5.0 | Ket 0.0 | Ket 10.0 | Ket 1.0 | MK 0.0 | MK 0.003 | MK 0.01 | MK 0.03 | Ifen 3.0 | Ifen 1.0 | Ifen 0.0 | Ifen 10.0 |
102 | Ascending | MK 0.01 | MK 0.0 | MK 0.003 | MK 0.03 | Ket 0.0 | Ket 1.0 | Ket 5.0 | Ket 10.0 | Ifen 0.0 | Ifen 10.0 | Ifen 1.0 | Ifen 3.0 |
103 | Ascending | Ket 0.0 | Ket 10.0 | Ket 1.0 | Ket 5.0 | MK 0.003 | MK 0.03 | MK 0.0 | MK 0.01 | Ifen 1.0 | Ifen 3.0 | Ifen 10.0 | Ifen 0.0 |
104 | Ascending | Ifen 1.0 | Ifen 3.0 | Ifen 10.0 | Ifen 0.0 | Ket 5.0 | Ket 10.0 | Ket 0.0 | Ket 1.0 | MK 0.003 | MK 0.03 | MK 0.01 | MK 0.0 |
105 | Descending | MK 0.03 | MK 0.01 | MK 0.0 | MK 0.003 | Ket 1.0 | Ket 0.0 | Ket 10.0 | Ket 5.0 | Ifen 10.0 | Ifen 0.0 | Ifen 3.0 | Ifen 1.0 |
106 | Descending | Ket 1.0 | Ket 5.0 | Ket 0.0 | Ket 10.0 | MK 0.03 | MK 0.01 | MK 0.003 | MK 0.0 | Ifen 3.0 | Ifen 0.0 | Ifen 1.0 | Ifen 10.0 |
107 | Descending | MK 0.0 | MK 0.003 | MK 0.03 | MK 0.01 | Ifen 0.0 | Ifen 3.0 | Ifen 10.0 | Ifen 1.0 | Ket 5.0 | Ket 0.0 | Ket 10.0 | Ket 1.0 |
108 | Descending | Ket 10.0 | Ket 1.0 | Ket 5.0 | Ket 0.0 | Ifen 10.0 | Ifen 0.0 | Ifen 1.0 | Ifen 3.0 | MK 0.03 | MK 0.003 | MK 0.0 | MK 0.01 |
109 | Ascending | Ifen 10.0 | Ifen 0.0 | Ifen 3.0 | Ifen 1.0 | Ket 10.0 | Ket 5.0 | Ket 1.0 | Ket 0.0 | MK 0.0 | MK 0.01 | MK 0.003 | MK 0.03 |
110 | Ascending | Ket 5.0 | Ket 0.0 | Ket 1.0 | Ket 10.0 | Ifen 3.0 | Ifen 1.0 | Ifen 0.0 | Ifen 10.0 | MK 0.003 | MK 0.03 | MK 0.0 | MK 0.01 |
111 | Ascending | MK 0.003 | MK 0.03 | MK 0.01 | MK 0.0 | Ifen 1.0 | Ifen 10.0 | Ifen 3.0 | Ifen 0.0 | Ket 0.0 | Ket 1.0 | Ket 5.0 | Ket 10.0 |
112 | Ascending | Ifen 3.0 | Ifen 1.0 | Ifen 0.0 | Ifen 10.0 | MK 0.01 | MK 0.0 | MK 0.03 | MK 0.003 | Ket 1.0 | Ket 10.0 | Ket 0.0 | Ket 5.0 |
113 | Descending | Ifen 0.0 | Ifen 10.0 | Ifen 1.0 | Ifen 3.0 | Ket 0.0 | Ket 5.0 | Ket 1.0 | Ket 10.0 | MK 0.01 | MK 0.0 | MK 0.03 | MK 0.003 |
114 | Descending | Ket 0.0 | Ket 10.0 | Ket 5.0 | Ket 1.0 | MK 0.0 | MK 0.003 | MK 0.03 | MK 0.01 | Ifen 1.0 | Ifen 10.0 | Ifen 3.0 | Ifen 0.0 |
115 | Descending | MK 0.01 | MK 0.03 | MK 0.0 | MK 0.003 | Ifen 0.0 | Ifen 10.0 | Ifen 3.0 | Ifen 1.0 | Ket 10.0 | Ket 5.0 | Ket 1.0 | Ket 0.0 |
116 | Descending | Ifen 1.0 | Ifen 10.0 | Ifen 3.0 | Ifen 0.0 | MK 0.003 | MK 0.03 | MK 0.01 | MK 0.0 | Ket 5.0 | Ket 1.0 | Ket 0.0 | Ket 10.0 |
Note: Ifen = ifenprodil; Ket = ketamine; MK = MK-801