Fig. 1.

Schematic representation of overlapping features of tumours harbouring FH, SDH, and IDH mutations. Mutations in FH, SDH, and IDH lead to the accumulation of fumarate, succinate, and 2HG, respectively, activating a plethora of signalling cascades. Converging signatures, mainly mediated by aKGDD inhibition, include pseudohypoxia, histone and DNA hypermethylation. The colour of text indicates metabolic alterations (red), epigenetic alterations (blue), post-translational modifications (green) and other pro-tumorigenic alterations (black) elicited by these metabolites. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)