Table 2.
Demographic details of subjects studied.
| Full series |
‘Matched’ seriesa |
|||
|---|---|---|---|---|
| Controls | Schizophrenia | Controls | Schizophrenia | |
| Number | 87 | 70 | 63 | 46 |
| Sex (male/female) | 59/28 | 43/27 | 46/17 | 32/14 |
| Age (years) | 42.0 (14.7) | 51.6 (15.5)⁎ | 42.7 (14.3) | 46.7 (13.9) |
| Race (C/AA/other)b | 28/52/7 | 26/40/4 | 21/38/4 | 18/25/3 |
| Hemisphere (R/L/not known)c | 15/59/13 | 9/55/6 | 9/46/8 | 7/36/3 |
| Brain weight (grams) | 1372 (152) | 1327 (161) | 1377 (151) | 1351 (153) |
| Brain pH | 6.55 (0.33) | 6.37 (0.29)⁎ | 6.56 (0.21) | 6.47 (0.23) |
| Post mortem interval (hours) | 32.5 (14.5) | 40.1 (19.8)⁎ | 33.5 (14.4) | 34.6 (13.9) |
| Smoker (yes/no/not known) | 21/63/3 | 51/19/0 | 16/44/3 | 37/9/0 |
| Suicide (yes/no/not known) | 0/87/0 | 11/58/1 | 0/63/0 | 10/36/0 |
| Age at onset of illness (years) | – | 23.3 (9.1) | – | 20.5 (6.0) |
| Duration of illness (years) | – | 28.3 (14.2) | – | 26.3 (12.7) |
| Antipsychotic detected (yes/no) | – | 42/28 | – | 27/19 |
| Daily CPZ equivalents (grams)d | – | 600 (100 − 3000) | – | 600 (100–3000) |
| rs10234440 genotype (TT/TC/CC)e | 65/19/2 | 56/12/2 | 46/15/1 | 38/7/1 |
Values are mean (SD).
⁎
Cases vs. controls, p < 0.01 (t-test).
a
Limited to subjects aged < 72 years, with post mortem interval < 72 h, and brain pH between 6.1 and 6.9. Cases and controls in this ‘matched’ series do not differ in age, pH or PMI (all p > 0.05).
b
C: Caucasian. AA: African American.
c
R: right. L: left.
d
CPZ: chlorpromazine. Range in brackets.
e
Not available for one control subject.