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Structure of the 5-HT3R, PDB: 4PIR
(A) The five subunits of the receptor are shown in different colors, with the approximate location of the lipid bilayer indicated by the gray spheres.
(B) Two of the five pore-lining M2 helices are shown along with the pore surface as defined by HOLE (Smart et al., 1996). Key pore-lining side chains are shown in space-filling format, with the hydrophobic gate formed by the V264 and L260 (i.e. L9′) rings in blue.
