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. 2016 Dec 6;24(12):2207–2216. doi: 10.1016/j.str.2016.10.005

Figure 5.

Figure 5

Electrowetting and the 5-HT3R M2 Pore

Attempted electrowetting of the 5-HT3R M2 pore by computational electrophysiology (CE) (Kutzner et al., 2011).

(A) CE simulation setup with two POPC membranes, each of which contains a single bundle of M2 helices (green/pink). Differences in ionic concentrations between the α and β regions generate a voltage difference (ΔV) across the lipid bilayer.

(B) The trajectories of water molecules (pale blue; see legend to Figure 3B for details) and of ions (Na+ red; Cl− blue) are shown for the two membranes of a CE simulation with a transbilayer voltage difference of ΔV = 800 mV.