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. 2016 Dec 6;24(12):2207–2216. doi: 10.1016/j.str.2016.10.005

Figure 6.

Figure 6

Water within the Zebrafish α1 GlyR

Simulations of water within the pore domains of three conformations (closed, PDB: 3JAD; open, PDB: 3JAE; and desensitized, PDB: 3JAF) of the zebrafish α1 GlyR.

(A) Longitudinal sections through the center of the pore lumen for the three structures of GlyR. Carbon atoms are colored yellow, and hydrophilic atoms are colored red. The approximate position of the channel within the membrane is marked by dotted lines. The positions of the L9′ (L277) and P-2′ (P266) rings, which constrict the pore, are indicated.

(B) Free-energy profiles for water (obtained by Boltzmann inversion of the water density within the pores) for the closed, open, and desensitized states of the GlyR pore. The vertical lines represent the locations on z of the L9′ and P-2′ rings.