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Schematic of Nef signaling pathways and their relationship with Nef’s biologic effects in podocytes. Nef activates both Stat3 and MAPK1,2 pathways via an Src-dependent pathway. Src activation is essential for Nef-induced podocyte proliferation and dedifferentiation. Stat3 and MAPK1,2 mediate these Nef effects in an additive manner. Other downstream signaling of Nef-Src interaction may also be important.
