Skip to main content
. 2004 Sep 1;114(5):720–728. doi: 10.1172/JCI21032

Figure 1.

Figure 1

Response of Stat3-deficient and control mice to TPA-induced epidermal hyperproliferation. (A–D) Groups of mice (n = 3) were treated topically with 4 applications of TPA and sacrificed 24 hours after the last treatment. BrdU was injected 30 minutes prior to sacrifice. H&E staining of epidermis from (A) untreated control mice, (B) control mice treated with TPA, (C) untreated Stat3-deficient mice, and (D) Stat3-deficient mice treated with TPA. (E) Quantitation of epidermal thickness from control (white bars) and Stat3-deficient (black bars) mice treated with different doses of TPA. (F) Percentage of BrdU-positive epidermal basal cells in control (white bars) and Stat3-deficient (black bars) mice treated with different doses of TPA. Scale bar: 50 μm. **P < 0.01 by Mann-Whitney U test.