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. 2016 Dec 9;6:171. doi: 10.3389/fcimb.2016.00171

Figure 4.

Figure 4

The expressions of CVB3 receptors on CD4+ T cells. (A) The expressions of CAR/DAF on nonactivated and activated CD4+ T cells were investigated. 293T and CHO cell lines were used as the CAR/DAF -positive and -negative controls respectively. (B) The CAR was not expressed on both nonactivated and activated CD4+ T cells (5 μg/ml anti-CD3, 2 μg/ml anti-CD28 stimulated for 3 days). The DAF was expressed on both nonactivated and activated CD4+ T cells, but the expressions of DAF between nonactivated and activated CD4+ T cells showed no difference. (C) The representative pictures of plaque assay for purified CD4+ T cells in mock, CVB3, CVB3+DAF mAb, CVB3+Isotype groups (all CD4+ T cells were isolated from peripheral blood in healthy controls). (D) The results of statistical analysis for CVB3 titers in these four groups. Values are means ± SEM. **P < 0.01 vs. Mock group; #P < 0.05 vs. CVB3 and CVB3+Isotype groups.