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Tailless-CCL21 depends on the same amino acid interactions as CCL21 for G-protein signaling.
| WT CCR7 | K137A | E193A | F133A | |
|---|---|---|---|---|
| CCL21 | 57.0 ± 0.7 | 16.0 ± 3.3 | 19.3 ± 4.6 | 28.7 ± 7.0 |
| Tailless-CCL21 | 42.7 ± 2.0 | 16.7 ± 5.1 | 17.5 ± 3.4 | 27.1 ± 10.3 |
Values annotate percentage activation of CCR7 (±SEM) in response to either CCL21 or tailless-CCL21 relative to CCL19.
