Sex differences in the distribution of DOR-SIG particles in CA3 pyramidal cell dendrites at baseline and following AIS. A. In control rats, the density of near plasmalemmal DOR-SIG particles in dendrites in significantly greater (*p < 0.05) in proestrus females compared to males. B. Compared to males, the partitioning ratio of DOR-SIG particles in dendrites was significantly elevated near the plasmalemma (*p < 0.05) and significantly less in the cytoplasm (*p < 0.05). C, D. AIS did not significantly alter the density of DOR-SIG particles in any cellular compartment in dendrites in either proestrus females or males. E. After AIS, there was a significant increase (*p < 0.05) in cytoplasmic density of DOR-SIG particles in large dendrites of proestrus females. F. After AIS, there was a significant increase in the near plasmalemma and total densities (*p < 0.05) of DOR-SIG particles in small dendrites of males. N = 3 rats group; n = 50 dendrites per rat.