Fig. 5.

Sex differences in the percentage of DOR-labeled dendritic spines that contact mossy fibers. A, B. Representative electron micrographs from an AIS proestrus female (A) and AIS male (B) show an example of a cytoplasmic DOR-SIG particle (arrow) in a dendritic spine (sp) contacted by a mossy fiber. Scale bar = 500 nm. C. After AIS, the percent of DOR-labeled spines contacted by mossy fibers significantly increases in males (*p < 0.05) but not proestrus females. D. After CIS, the percent DOR-labeled spines contacted by mossy fibers approaches a significant decrease (ˆp = 0.053) in diestrus females. N = 3 rats group; n = 50 mossy fibers per rat.