Table 1. Functionally enriched terms among genes significantly up/down regulated in Spalax vs. rat, in the brain, at above two fold change.
| Category | Functional terms | Adjusted p values |
||||
|---|---|---|---|---|---|---|
| CP | GP | GS | GR | DE | ||
| Log2FC > 1.0 Adj. p < 0.05 Spalax > rat brain | (I) DNA metabolic process | 5.7E-07 | 2.3E-04 | 2.6E-04 | 2.6E-05 | 102 |
| (I) DNA replication/DNA-dependent DNA replication | 2.7E-03 | 9.6E-03 | 1.3E-02 | 8.6E-03 | 23 | |
| (I) DNA repair | 1.4E-03 | 4.1E-03 | 2.0E-02 | 1.7E-02 | 59 | |
| (I) Fanconi Anemia pathway (KEGG) | 1.1E-02 | 6.3E-02 | 13 | |||
| (I) cellular response to DNA damage stimulus | 1.4E-03 | 9.4E-02 | 2.1E-01 | 79 | ||
| (I) DNA recombination/recombinational repair | 7.8E-03 | 5.7E-03 | 29 | |||
| (II) homologous chromosome segregation | 7.8E-03 | 2.2E-02 | 9.4E-02 | 4.4E-01 | 11 | |
| (II) kinetochore/condensed chromosome kinetochore | 5.7E-03 | 5.0E-02 | 2.0E-02 | 1.4E-02 | 22 | |
| (II) chromosomal region/centromeric region | 5.7E-03 | 7.9E-03 | 9.4E-02 | 1.4E-02 | 38 | |
| (II) Cell cycle/Mitotic Metaphase | 8.1E-02 | 9.5E-02 | 4.6E-02 | 88 | ||
| (III) extracellular matrix/proteinaceous extracellular matrix | 2.9E-05 | 3.2E-02 | 3.6E-02 | 1.9E-09 | 56 | |
| (III) heparin binding | 4.7E-03 | 20 | ||||
| (III) ECM-receptor interaction | 1.6E-02 | 9.5E-02 | 17 | |||
| Log2FC < 1.0 Adj. p < 0.05 Spalax < rat brain | (IV) extracellular space | 5.9E-09 | 1.9E-06 | 2.4E-03 | 1.4E-05 | 119 |
| (IV) extracellular vesicle/lysosome/exosome | 8.7E-03 | 1.9E-06 | 1.5E-02 | 2.7E-03 | 254 | |
| (V) G-protein coupled receptor activity/G-protein complex | 8.1E-03 | 5.4E-02 | 6.8E-02 | 75 | ||
Category column: (1) genes significantly up-regulated in Spalax vs. rat, in the brain, with at least two fold increase (log2FC > 1.0); (2) genes down-regulated, with least two fold decrease (log2FC < −1.0); Terms column: groups of functionally-related terms are marked in Roman numerals; Adjusted p values heatmap: FDR-corrected p values reported by the programs cluster-profiler (CP), g-profiler (GP), goseq (GS), and Gorilla (GR). The total count of DE genes is shown in the last column (DE). Note that Gorilla tool does not include a KEGG/Reactome databases, and terms that were not tested, or were not found to be enriched by specific tools, are shown as blank cells. Significant p-values are underlined, and p-values > 10−1 in italics.