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. 2016 Dec 9;6:38694. doi: 10.1038/srep38694

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Copyright © 2016, The Author(s)

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(A) BSEP function was inhibited by cholestatic drugs in hiHeps compared with SCHHs, resulting in a decrease in the BEI value of d8-TCA. The cholestatic drugs included 10 μmol/L troglitazone, 30 μmol/L ketoconazole, 25 μmol/L rifampicin, 25 μmol/L bosentan, 10 μmol/L glibenclamide and 100 μmol/L omeprazole. The data are expressed as the mean ± SD (n = 3). (B) BSEP expression was inhibited by cholestatic drugs in hiHeps (white columns) compared with SCHHs (grey columns). The data are expressed as the mean ± SD (n = 3). *p < 0.05 vs control. (C) Correlation analysis of hiHeps and human hepatocytes based on the log(IC50) determined by MTT assay. The calculated r² value of the linear correlation between hiHeps and human hepatocytes was 0.8032.