Table 3.
Cross-sectional association of markers of kidney disease with echocardiographic measures among participants in the Jackson Heart Study
| LVM, β (95% CI) | LVEF, β (95% CI) | |
|---|---|---|
| eGFR (per 10 mL/min/1.73 m2 decrease) | ||
| Unadjusted | 3.89 (3.17, 4.61) | 0.03 (−0.10, 0.17) |
| Model 1 | 2.08 (1.67, 2.48) | −0.15 (−0.23, −0.08) |
| Model 2 | 1.54 (0.78, 2.31) | −0.12 (−0.28, 0.04) |
| Model 3 (mediation) | 1.26 (0.52, 1.99) | −0.13 (−0.28, 0.03) |
| eGFR <60 mL/min/1.73 m2 (ref ≥60 mL/min/1.73 m2) | ||
| Unadjusted | 25.86 (19.22, 32.51) | −0.72 (−1.94, 0.49) |
| Model 1 | 18.93 (15.70, 22.16) | −1.51 (−2.13, −0.88) |
| Model 2 | 10.62 (4.34, 16.91) | −1.07 (−2.38, 0.23) |
| Model 3 (mediation) | 11.08 (5.03, 17.13) | −1.09 (−2.40, 0.22) |
| ACR ≥30 g/mg (ref <30 g/mg) | ||
| Unadjusted | 22.31 (16.86, 27.77) | −0.46 (−1.60, 0.68) |
| Model 1 | 18.74 (13.71, 23.76) | −0.64 (−1.71, 0.43) |
| Model 2 | 10.98 (6.20, 15.76) | −0.51 (−1.69, 0.66) |
| Model 3 (mediation) | 7.58 (2.65, 12.51) | −0.57 (−1.77, 0.62) |
| ACR (per doubling) | ||
| Unadjusted | 4.89 (3.78, 6.00) | −0.28 (−0.21, 0.15) |
| Model 1 | 4.39 (3.36, 5.42) | −0.14 (−0.35, 0.08) |
| Model 2 | 2.87 (1.85, 3.88) | −0.11 (−0.35, 0.12) |
| Model 3 (mediation) | 1.95 (0.96, 2.95) | −0.13 (−0.36, 0.10) |
Values presented as mean (95% CI) difference in LVM and LVEF.
Model 1: Adjusted for age, sex and education.
Model 2: Model 1 + BMI, tobacco use, LDL cholesterol, HDL cholesterol, lipid-lowering medications, history of CHD, history of stroke, history of diabetes, hemoglobin and eGFR/ACR (adjusting for the alternative kidney disease marker).
Model 3: Model 2 + systolic blood pressure, diastolic blood pressure and hypertension medications. ref, reference.