Increasing concentrations of IVIg significantly increased the level of Bcl2 during GD-induced neuronal cell death (a and b). Aβ42 treatment decreased the expression level of Bcl2, however treatment with increasing concentrations of IVIg increased Bcl2 expression level in Aβ42-treated cultures (c and d). **, P < 0.05 compared to vehicle; ***, P < 0.001 compared to vehicle; +, P < 0.05 compared to Aβ42 treated group; +++, P < 0.001 compared to Aβ42-treated group; n = 3 or more biologically different cultures in each group.