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. Author manuscript; available in PMC: 2016 Dec 9.
Published in final edited form as: J Neurochem. 2012 Apr 27;122(2):321–332. doi: 10.1111/j.1471-4159.2012.07754.x

Figure 6. IVIg treatment reduces neuronal cell death in vivo following ischemic stroke.

Figure 6

a. Intravenously-injected IVIg reached the brain as a result of blood brain barrier breakdown. (Scale bars: 100 μM.) b-d. MAP2-positive neuronal cells were significantly decreased in number in infarcted brain area whereas the treatment with IVIg in both pre- and post-treatment significantly reduced the amount of neuronal loss in infarcted area. ***, P < 0.05 compared to MCAO/R group; n = 3-6 in each group. e and f. TUNEL staining showed that both pre- and post-treatment of IVIg decreased the amount of cell apoptosis in the infarcted region of the brain. ***, P < 0.05 compared to MCAO/R group; n = 3-6 in each group.