Supplementary Table 4.

The definition of primary endpoint of RCTs

Study, year	The definition of primary endpoint
EXCELLENT, 2012	TVF: A composite of cardiac death, MI, or TVR
OPTIMIZE, 2013	NACCE: Composite of all-cause death, MI, stroke, or major bleeding
RESET, 2012	NACE: A composite of cardiac death, MI, ST, TVR, or bleeding
SECURITY, 2016	A composite of cardiac death, MI, stroke, definite or probable ST, or BARC Type 3 or 5 bleeding
DAPT, 2014	MACCE: Death, MI, stroke
REAL/ZEST-LATE, 2010	MI or cardiac death

BARC: Bleeding Academic Research Consortium; MACCE: Major adverse cardiac and cerebrovascular event; MI: Myocardial infarction; NACE: Net adverse cardiac event; NACCE: Net adverse cardiac and cerebrovascular event; ST: Stent thrombosis; TVF: Target vessel failure; TVR: Target vessel revascularization; DAPT: Dual antiplatelet therapy; RCTs: Randomized controlled trials.