Table 6.
Adverse events in patients treated as adjuvant/first-line setting (n = 32)
| Adverse event | G0 | G1 | G2 | G3 | G4 | NE | All grades (%) | Grade 3/4 (%) |
|---|---|---|---|---|---|---|---|---|
| Leucocyte | 3 | 3 | 8 | 10 | 7 | 1 | 87.5 | 53.1 |
| Neutrophils | 2 | 3 | 5 | 8 | 13 | 1 | 90.6 | 65.6 |
| Hemoglobin | 10 | 8 | 8 | 5 | 0 | 1 | 65.6 | 15.6 |
| Platelets | 19 | 3 | 6 | 3 | 0 | 1 | 37.5 | 9.4 |
| AST | 22 | 6 | 2 | 1 | 0 | 1 | 28.1 | 3.1 |
| ALT | 22 | 5 | 1 | 3 | 0 | 1 | 28.1 | 9.4 |
| Anorexia | 13 | 14 | 5 | 0 | 0 | 0 | 59.4 | 0.0 |
| Nausea | 17 | 11 | 4 | 0 | 0 | 0 | 46.9 | 0.0 |
| Vomiting | 26 | 5 | 1 | 0 | 0 | 0 | 18.8 | 0.0 |
| Diarrhea | 26 | 4 | 1 | 1 | 0 | 0 | 18.8 | 3.1 |
| Fatigue | 14 | 12 | 5 | 1 | 0 | 0 | 56.3 | 3.1 |
| Febrile neutropenia | 29 | 0 | 0 | 3 | 0 | 0 | 9.4 | 9.4 |
| Fever | 24 | 6 | 1 | 1 | 0 | 0 | 25.0 | 3.1 |
| Infection | 29 | 0 | 1 | 2 | 0 | 0 | 9.4 | 6.3 |
| Dyspnea | 31 | 0 | 0 | 1 | 0 | 0 | 3.1 | 3.1 |
| Interstitial pneumonia | 30 | 2 | 0 | 0 | 0 | 0 | 6.3 | 0.0 |
| Neuropathy | 32 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0.0 |
| Rash | 24 | 4 | 3 | 1 | 0 | 0 | 25.0 | 3.1 |
| Edema | 30 | 2 | 0 | 0 | 0 | 0 | 6.3 | 0.0 |
| Mucositis | 31 | 0 | 1 | 0 | 0 | 0 | 3.1 | 0.0 |
| Allergic reaction | 32 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0.0 |
AST aspartate transaminase, ALT alanine aminotransferase