Table 1.
Demographics and clinical characteristics of the study groups
| Characteristic | NCI (n = 18) | MCI (n = 9) | AD (n = 7) |
|---|---|---|---|
| Age at death (yrs) | 86.3 (6.4) | 84.9 (6.8) | 92.4 (4.7) |
| Male : Female | 6 : 12 | 5 : 4 | 2 : 5 |
| Education (yrs) | 17.8 (3.2) | 18.0 (1.8) | 17.9 (2.1) |
| Post mortem interval, median (IQR) | 5.6 (5.3–6.3) | 5.1 (4.5–7.3) | 5.8 (4.5–13.3) |
| Apolipoprotein E ε4, n (%) | 3 (16.7%) | 2 (11.1%) | 0 |
| Mini mental state exam (MMSE) | 28.3 (1.8) | 26.7 (1.9) | 14.4 (8.3) |
| Cognitive test scores | |||
| Global Cognitive Scores | 0.03 (0.4) | −0.4 (0.5) | −1.6 (0.8) |
| Episodic memory | 0.4 (0.6) | −0.3 (0.9) | −2.2 (1.3) |
| Working memory | −0.02 (0.5) | −0.4 (0.8) | −0.8 (0.4) |
| Semantic memory | −0.1 (0.6) | −0.3 (0.6) | −1.3 (0.9) |
| Visuospatial activity | −0.1 (0.6) | −0.4 (0.9) | −1.2 (0.3) |
| Perceptual Speed | −0.3 (0.5) | −0.9 (0.7) | −1.6 (0.4) |
| Braak Stages, n (%) | |||
| 0 | 1 (5.6%) | 0 | 0 |
| I | 1 (5.6%) | 1 (11.1%) | 0 |
| II | 0 | 2 (22.2%) | 1 (14.3%) |
| III | 10 (55.6%) | 3 (33.3%) | 1 (14.3%) |
| IV | 6 (33.3%) | 3 (33.3%) | 1 (14.3%) |
| V | 0 | 0 | 4 (57.1%) |
Data represent the mean and (SD). For Braak stage the number of cases and the % in each group (NCI, MCI or AD)