Table 2.
AON and ERC immunostaining levels in NCI, MCI and AD
| Region of interest | Clinical Diagnosis | Active Casp6 | TauΔCasp6 | PHF-1 | Aβ | |
|---|---|---|---|---|---|---|
| AON | NCI | Median | 837.7 | 472.9 | 3655.9 | 403.3 |
| IQR | 289.0–1481.8 | 263.0–4182.6 | 1248.2–23248.5 | 109.9–658.2 | ||
| n | 11 | 11 | 11 | 10 | ||
| MCI | Median | 226.1 | 980.7 | 7494.4 | 452.9 | |
| IQR | 118.1–2705.2 | 458.0–9493.4 | 651.1–67082.5 | 136.3–2993.1 | ||
| n | 6 | 6 | 7 | 7 | ||
| AD | Median | 23982.4 | 20400.0 | 75146.7 | 27355.0 | |
| IQR | 11445.0–26221.2 | 3087.2–54521.9 | 41473.2–151857.4 | 1222.9–55633.7 | ||
| n | 4 | 4 | 5 | 5 | ||
| ERC | NCI | Median | 69.7 | 29.3 | 4138.2 | 940.7 |
| IQR | 53.8–518.3 | 10.8–1138.3 | 615.9–16672.1 | 106.5–3406.6 | ||
| n | 8 | 9 | 9 | 9 | ||
| MCI | Median | 662.4 | 1035.8 | 15562.1 | 96.1 | |
| IQR | 14.4–1639.4 | 246.8–3901.1 | 9394.8–42729.6 | 54.2–4787.4 | ||
| n | 7 | 7 | 7 | 7 | ||
| AD | Median | 1022.1 | 7859.5 | 56051.4 | 14342.6 | |
| IQR | 497.2–1453.1 | 3181.4–18251.4 | 53590.7–70360.4 | 11159.6–24689.1 | ||
| n | 4 | 5 | 3 | 5 |
Data represent the median (μm2 staining/μm2 tissue) and the Inter-Quartile Range (25% percentile-75% percentile). n indicates the number of cases studied with each immunostaining in this region of interest. Comparisons of distributions for pathological markers by clinical diagnosis were done separately in the AON and in the ERC using the Kruskal-Wallis test, followed by a Dunn’s post-hoc test where warranted (results and p values are reported in the text)