Table 3.

Ridge regression coefficients of cognitive performance scores from AON and ERC pathologies

	AON (n = 19)			ERC (n = 18)
Predicting cognition	Marker	Coefficient	p value	Marker	Coefficient	p value
GCS	Active Casp6	−0.18	0.01	Active Casp6	−0.02	0.40
	TauΔCasp6	−0.08	0.29	TauΔCasp6	−0.05	0.06
	PHF-1	−0.06	0.33	PHF-1	−0.03	0.27
	Aβ	−0.18	0.04	Aβ	−0.03	0.27
MMSE	Active Casp6	−1.97	0.001	Active Casp6	−0.29	0.23
	TauΔCasp6	−1.36	0.05	TauΔCasp6	−0.72	0.01
	PHF-1	−0.92	0.06	PHF-1	−0.41	0.04
	Aβ	−0.90	0.21	Aβ	−0.30	0.14
Episodic Memory	Active Casp6	−0.31	0.01	Active Casp6	−0.02	0.67
	TauΔCasp6	−0.13	0.32	TauΔCasp6	−0.07	0.07
	PHF-1	−0.14	0.17	PHF-1	−0.05	0.24
	Aβ	−0.28	0.05	Aβ	−0.05	0.27
Working memory	Active Casp6	−0.06	0.26	Active Casp6	−0.02	0.21
	TauΔCasp6	−0.03	0.59	TauΔCasp6	−0.01	0.64
	PHF-1	−0.004	0.93	PHF-1	−0.004	0.81
	Aβ	−0.09	0.16	Aβ	0.001	0.95
Semantic memory	Active Casp6	−0.15	0.03	Active Casp6	−0.01	0.69
	TauΔCasp6	−0.11	0.14	TauΔCasp6	−0.05	0.05
	PHF-1	−0.07	0.25	PHF-1	−0.02	0.55
	Aβ	−0.16	0.06	Aβ	−0.03	0.28
VSA	Active Casp6	−0.09	0.12	Active Casp6	−0.01	0.62
	TauΔCasp6	−0.01	0.91	TauΔCasp6	−0.01	0.84
	PHF-1	0.02	0.72	PHF-1	−0.01	0.57
	Aβ	−0.06	0.41	Aβ	−0.03	0.21
PS	Active Casp6	−0.08	0.23	Active Casp6	−0.05	0.05
	TauΔCasp6	−0.07	0.32	TauΔCasp6	−0.05	0.04
	PHF-1	−0.02	0.71	PHF-1	−0.02	0.29
	Aβ	−0.04	0.64	Aβ	−0.02	0.31

Data represent the ridge regression analysis of the different markers in the AON and the ERC and the cognitive scores. Model adjusted for sex, age, PMI and years of education, in bold p values less or equal to 0.05