Table 3.
Absolute risk estimated from the predicted OR, by the PRS percentiles
| Shanghai Chinese women | Korean women | ||||
|---|---|---|---|---|---|
| PRS (%) | Predicted OR | Lifetime risk (%)a | 10-year risk (%)b | Lifetime risk (%)a | 10-year risk (%)b |
| 0–1 | 0.37 | 1.35 | 0.38 | 1.31 | 0.39 |
| 0–10 | 0.52 | 1.89 | 0.53 | 1.85 | 0.55 |
| 10–20 | 0.67 | 2.44 | 0.69 | 2.38 | 0.70 |
| 20–30 | 0.77 | 2.80 | 0.79 | 2.73 | 0.81 |
| 30–40 | 0.86 | 3.13 | 0.88 | 3.05 | 0.90 |
| 40–60 | 1.00 | 3.64 | 1.03 | 3.55 | 1.05 |
| 60–70 | 1.16 | 4.22 | 1.19 | 4.12 | 1.22 |
| 70–80 | 1.29 | 4.69 | 1.32 | 4.58 | 1.35 |
| 80–90 | 1.49 | 5.42 | 1.53 | 5.28 | 1.56 |
| 90–100 | 1.97 | 7.16 | 2.02 | 6.98 | 2.07 |
| 99–100 | 2.77 | 10.06 | 2.84 | 9.81 | 2.90 |
aLifetime risk: the risk of developing breast cancer from age 20 to 80
bTen-year risk: the risk of developing breast cancer from age 50 to 60
OR odds ratio, PRS polygenic risk score