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. 2016 Dec 8;16:91. doi: 10.1186/s12935-016-0367-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — PlasDIC images of MCF-7 and MDA-MB-231 cells exposed to the compound with/or without 3MA for 24 h. i MCF-7 cells and ii MDA-MB-231 cells grown in a DMSO and b 3MA served as negative controls. Confluent cell growth with no signs of cell distress was demonstrated. c Actinomycin D (0.1 μg/ml) served as a positive control for apoptosis, resulting in apoptotic body formation and compromised cell density. d ESE-15-ol-treated cells revealed the presence of rounded cells, formation of apoptotic bodies and decreased cell density. e ESE-15-ol exposure to cells in which autophagy had been inhibited with 3MA showed an increase in cell viability. (Arrow colour key: Yellow = interphase cells; orange = rounded cells in metaphase; white = apoptotic bodies.)