Table 3.
Putative transporters in Cryptosporidium spp. and other common apicomplexan parasitesa
| Substrates | Cellular location | Cpar | Chom | Cubi | Cand | Pfal | Tgon |
|---|---|---|---|---|---|---|---|
| Hexose | 2 | 2 | 2 | 2 | 2 | 5 | |
| Triose phosphate | Plasma/Apicoplast membrane | 8 | 5 | 8 | 8 | 4 | 4 |
| Amino acids | Plasma membrane | 10 | 10 | 10 | 12 | 1 | 6 |
| Nucleobase/nucleoside | Plasma membrane | 1 | 1 | 1 | 1 | 4 | 4 |
| Nucleotide-sugar | Plasma membrane | 3 | 3 | 3 | 2 | 1 | 4 |
| Folate/pterine | Plasma membrane | 1 | 1 | 1 | 1 | 2 | 7 |
| Formate/nitrite | 0 | 0 | 0 | 0 | 1 | 3 | |
| GABA (aminobutanoate) | Plasma/Mitochondrial membrane | 0 | 0 | 0 | 0 | 2 | 5 |
| Acetyl-CoA | 1 | 0 | 1 | 1 | 1 | 1 | |
| Chloride | 0 | 0 | 0 | 0 | 0 | 2 | |
| Inorganic phosphate | 0 | 0 | 0 | 0 | 1 | 1 | |
| Sulfate | 1 | 1 | 1 | 1 | 1 | 4 | |
| Sodium/potassium/calcium | 2 | 2 | 2 | 3 | 0 | 9 | |
| Zinc | 2 | 2 | 2 | 2 | 2 | 4 | |
| Copper | 1 | 1 | 1 | 1 | 2 | 3 | |
| Choline | Plasma membrane | 0 | 0 | 0 | 0 | 1 | 2 |
| Cadmium/zinc/cobalt (efflux) | Plasma membrane | 1 | 1 | 1 | 1 | 1 | 1 |
| Glycerol/water | Plasma membrane | 0 | 0 | 0 | 0 | 2 | 2 |
| ABC transporterb | Plasma membrane | 21 | 18 | 21 | 21 | 16 | 24 |
| Mitochondrial carrierb | Mitochondrial membrane | 9 | 7 | 6 | 13 | 14 | 21 |
aThe detection of these transporter proteins was based on the Pfam search results
bABC transporters and mitochondrial carriers have a broad range of substrates
Cpar Cryptosporidium parvum, Chom C. hominis, Cubi C. ubiquitum, Cand C. andersoni, Pfal Plasmodium falciparum Pfal, Tgon Toxoplasma gondii