Table 3. Replication and Combined analysis of significant HLA-DRB1 alleles.
| HLA-DRB1 alleles | Replication analysis |
Combined analysis |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IMN (2n = 258) |
Control (2n = 772) |
OR (95% CI)a | P-valueb | P-valuec corrected | IMN (2n = 364) |
Control (2n = 1610) | % | OR (95% CI)a | P-valueb | P-valuec corrected | ||||
| No | % | No | % | No | % | No | ||||||||
| DRB1*0101 | 11 | 4.3 | 59 | 7.6 | 0.54 (0.28–1.04) | 0.06 | N.S. | 13 | 3.6 | 116 | 7.2 | 0.48 (0.27–0.86) | 0.01 | 0.33 |
| DRB1*0401 | 9 | 3.5 | 11 | 1.4 | 2.50 (1.02–6.10) | 0.03 | 0.77 | 12 | 3.3 | 21 | 1.3 | 2.58 (1.26–5.29) | 7.42E-03 | 0.22 |
| DRB1*0405 | 24 | 9.3 | 79 | 10.2 | 0.90 (0.56–1.45) | 0.67 | N.S. | 31 | 8.5 | 201 | 12.5 | 0.65 (0.44–0.97) | 0.03 | 0.98 |
| DRB1*1101 | 12 | 4.7 | 15 | 1.9 | 2.46 (1.14–5.33) | 0.02 | 0.53 | 18 | 4.9 | 38 | 2.4 | 2.15 (1.21–3.82) | 7.31E-03 | 0.21 |
| DRB1*1302 | 9 | 3.5 | 63 | 8.2 | 0.41 (0.20–0.83) | 3.49E-03 | 0.10 | 12 | 3.3 | 128 | 8.0 | 0.39 (0.22–0.72) | 1.79E-03 | 0.05 |
| DRB1*1454 | 16 | 6.2 | 23 | 3.0 | 2.15 (1.12–4.14) | 0.02 | 0.55 | 22 | 6.0 | 49 | 3.0 | 2.05 (1.22–3.43) | 5.50E-03 | 0.16 |
| DRB1*1501 | 52 | 20.2 | 54 | 7.0 | 3.36 (2.22–5.06) | 1.71E-09 | 4.97E-08 | 73 | 20.1 | 121 | 7.5 | 3.09 (2.25–4.24) | 3.94E-13 | 1.14E-11 |
aOR: Odds ratio; 95% CI: lower and upper limits of confidence interval at 95%.
bP-value for allele or genotype frequency comparisons between cases and controls using the chi-square test.
cP-value: Corrected P-value for the number of alleles tested.