Table 6. Interaction analysis between HLA-DRB1*15:01-DQB1*06:02 haplotype and PLA2R1 risk variants.
| HLA | PLA2R1 | IMN (N = 177) |
Controls (N = 792) |
OR (95%CI) | P-value | ||
|---|---|---|---|---|---|---|---|
| No | % | No | % | ||||
| DRB1*15:01-DQB1*06:02 | rs1511223: A/A | ||||||
| + | + | 45 | 25.4 | 44 | 5.5 | 9 (5.32–15.24) | 1.25E-19 |
| + | − | 17 | 9.6 | 65 | 8.2 | 2.3 (1.23–4.3) | 7.44E-03 |
| − | + | 74 | 41.8 | 323 | 40.7 | 2.02 (1.34–3.04) | 6.78E-04 |
| − | − | 41 | 23.2 | 360 | 45.5 | 1 | |
| DRB1*15:01-DQB1*06:02 | rs35771982: G/G | ||||||
| + | + | 41 | 23.2 | 27 | 3.4 | 15.91 (8.94–28.3) | 2.76E-29 |
| + | − | 21 | 11.9 | 82 | 10.4 | 2.68 (1.52–4.75) | 4.74E-04 |
| − | + | 71 | 40.1 | 222 | 28.0 | 3.35 (2.23–5.04) | 1.78E-09 |
| − | − | 44 | 24.9 | 461 | 58.2 | 1 | |
| DRB1*15:01-DQB1*06:02 | rs2715928: A/A | ||||||
| + | + | 33 | 18.6 | 15 | 1.9 | 17.53 (9.03–34.03) | 4.26E-26 |
| + | − | 29 | 16.4 | 94 | 11.9 | 2.46 (1.5–4.02) | 2.35E-04 |
| − | + | 51 | 28.8 | 173 | 21.8 | 2.35 (1.56–3.53) | 2.68E-05 |
| − | − | 64 | 36.2 | 510 | 64.4 | 1 | |
| DRB1*15:01-DQB1*06:02 | rs16844715: C/C | ||||||
| + | + | 34 | 19.2 | 18 | 2.3 | 15.91 (8.49–29.79) | 2.30E-26 |
| + | − | 28 | 15.8 | 91 | 11.5 | 2.59 (1.58–4.26) | 1.13E-04 |
| − | + | 51 | 28.8 | 144 | 18.2 | 2.98 (1.98–4.5) | 1.98E-07 |
| − | − | 64 | 36.2 | 539 | 68.1 | 1 | |
| DRB1*15:01-DQB1*06:02 | rs3749119: C/C | ||||||
| + | + | 41 | 23.2 | 27 | 3.4 | 15.86 (8.9–28.26) | 6.42E-29 |
| + | − | 21 | 11.9 | 82 | 10.4 | 2.67 (1.51–4.74) | 5.21E-04 |
| − | + | 72 | 40.7 | 234 | 29.5 | 3.21 (2.13–4.84) | 7.29E-09 |
| − | − | 43 | 24.3 | 449 | 56.7 | 1 | |