Figure 4. Exogenous ADP restores TAIII-inhibited platelet aggregation and dense granule secretion in response to stimulation with U46619.

Rat PRP was preincubated with TAIII (7.5 μmol/L) for 3 min and then stimulated with U46619 (2.5 μmol/L) with or without immediate ADP treatment (0.25 μmol/L). (a) Typical real-time ATP secretion and platelet aggregation traces are representative of three independent experiments. (b) Quantification of aggregation (%) is presented as the mean ± SEM.