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. 2016 Dec 9;6:38757. doi: 10.1038/srep38757

Figure 8. TAIII impairs primary hemostasis and prevents thrombus formation.

Figure 8

(a) Mice were administered saline (vehicle), TAIII (10, 20 or 40 mg/kg) or aspirin (40 mg/kg) (n = 15 per group), and bleeding time was recorded. (b) Mice were administered saline, TAIII (10, 20 or 40 mg/kg) or aspirin (40 mg/kg) (n = 10 per group), and survival time after collagen-epinephrine-induced pulmonary thromboembolism was recorded. The horizontal line indicates the mean bleed time (or survival time); each symbol represents one animal. Statistical significance was determined by the Mann-Whitney test. *p < 0.05, **p < 0.01, compared with the vehicle-treated group. (c) Rats were administered saline, TAIII (10, 20 or 40 mg/kg) or aspirin (40 mg/kg) (n = 6 per group), and the wet weight and dry weight of the thrombus were measured. The bar graph represents the mean ± SEM (n = 6). Statistical significance was determined by Student’s t-test. *p < 0.05, compared with the saline-treated group.