Table 2. Analysis of associations between SNPs from DROSHA, DGCR8, XPO5, RAN, and DICER1 and cancer risk.

Gene(locus)	Position	studies	Method	Cases /controls	WW vs.WM+MMa	Pb	I2	WW vs. WM+MMa	Pc	I2	WW vs.WM+MMa	Pd	I2
					ORb(95% CI)			ORc(95% CI)			ORd(95% CI)
DROSHA(5p13.3)
rs10719 T>C	3′UTR	5	R	1982/2293	0.91(0.75,1.10)	0.209	36.2	1.34(0.78,2.30)	0.070	69.6	1.05(0.83,1.33)	0.026	63.9
DGCR8(22q11.2)
rs417309 G>Ae	3′UTR	7	F	3327/3658	1.44(1.13,1.83)	0.561	0.0	1.04(0.78,1.39)	0.147	47.8	1.22(1.04,1.42)	0.190	31.2
rs1640299 T>G	3′UTR	7	R	2610/3046	1.07(0.90,1.28)	0.571	0.0	1.22(0.85,1.75)	0.017	70.7	1.20(0.94,1.54)	0.038	46.1
XPO5(6p21.1)
rs11077 A>G	3′UTR	7	F	8065/5478	0.83(0.66,1.03)	0.652	0.0	0.95(0.88,1.03)	0.260	25.7	0.94(0.87,1.01)	0.463	0.0
RAN(12q24.3)
rs14035 C>T	3′UTR	9	R	7702/5335	1.40(0.72,2.69)	0.001	92.6	0.99(0.73,1.33)	0.002	79.2	1.17(0.87,1.57)	0.000	88.7
rs3803012 A>G	3′UTR	5	F	5642/6489	0.98(0.87,1.11)	0.494	0.0	–	–	–	–	–	–
DICER1(14q32.13)
rs1057035 T>C	3′UTR	10	F	7783/8925	1.13(1.04,1.22)	0.163	33.2	1.21(0.90,1.62)	0.182	44.0	1.13(1.05,1.22)	0.188	27.8
rs3742330 A>G	3′UTR	9	R	3222/3240	1.02(0.89,1.18)	0.000	79.6	0.90(0.73,1.10)	0.396	0.0	0.98(0.87,1.10)	0.001	70.9
rs13078 T>A	3′UTR	7	F	3102/3419	1.01(0.81,1.26)	0.889	0.0	1.13(0.97,1.32)	0.116	49.3	1.09(0.96,1.24)	0.339	11.8

Notes.

^aW: major allele M: minor allele.

^bAsian population.

^cCaucasian population.

^dAll over.

^eWM+MM vs. WW.

Method: F, Fixed model; R, Random model.