. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: Med Res Rev. 2016 Jun 12;36(5):964–979. doi: 10.1002/med.21397

Table 1.

Disease status and OAT expression

Disease status		Models	Transporters	RNA/protein	Change	Ref
Chronic renal failure (CRF)		5/6 Nephrectomized rat	rOat1, rOat2, rOat3	mRNA/protein	￬	^17,18
Acute renal failure (ARF)		Rat with renal ischemia	rOat1, rOat3	mRNA/protein	￬	^19,20
Bilateral ureteral obstruction (BUO)		Rat with bilateral obstruction of the proximal ureters	rOat1, rOat3	Surface protein	￬	²¹
Diabetes	Type I diabetes	streptozotocin (STZ) induced diabetic rat	rOat3	protein	￬	²³
	Type I diabetes	Ins2Akita mouse	mOat1, mOat2 mOat3, mOat5	mRNA/protein	￬	²⁴
	Type II diabetes	Ob/Ob (Obese) mouse	mOat2	mRNA	￬	²⁶
		Db/Db (diabetic) mouse	mOat2	mRNA	￬	²⁷
		STZ induced diabetic rat with high-fat diet	rOat2	protein	￪	²⁵
Cholestasis		ANIT induce intrahepatic cholestasis rat	rOat1, rOat3	mRNA/protein	￬	²⁸
		Bile duct ligation (BDL) rat	rOat1	protein	￬	²⁹
		Bile duct ligation (BDL) rat	rOat3	protein	￪	²⁹