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. Author manuscript; available in PMC: 2017 Apr 6.
Published in final edited form as: Small. 2016 Feb 8;12(13):1758–1769. doi: 10.1002/smll.201502458

Figure 6. Biodistribution and targeting of TMV-PEG-RGD VNPs.

Figure 6

Representative Maestro fluorescence images showing the biodistribution of VNPs displaying RGD, in a HT-29 cancer mouse model. RGD-targeted TMV accumulates preferentially in HT-29 tumor xenografts in mice with reduced accumulation in liver/spleen (while PEGylated accumulates in liver/spleen > tumor). Maestro imaging of tumors, liver and spleen (n=3; signals shown as heat map.