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Study treatment sequences.
| Treatment sequence | Period 1 | Period 2 | Period 3 |
|---|---|---|---|
| Sequence 1 | HSWG | RCS | RCD |
| Sequence 2 | RCD | HSWG | RCS |
| Sequence 3 | RCS | RCD | HSWG |
| Sequence 4 | HSWG | RCD | RCS |
| Sequence 5 | RCD | RCS | HSWG |
| Sequence 6 | RCS | HSWG | RCD |
Abbreviations: HSWG = high-sheer wet granulation; PK = pharmacokinetic; RCD = roller compaction dry-milled; RCS = roller compaction slurry-milled.
