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. 2016 Dec 2;5:212303. doi: 10.7573/dic.212303

Table 4.

Analysis of tmax of galunisertib.

Parameter Formulation, 150 mg N Median (min, max) Median difference RCD/RCS – HSWG (90% CI)
tmax (h) HSWG 13 1.00 (0.50, 3.00)
RCD 13 2.00 (0.50, 3.17) 0.59 (0.00, 1.25)
RCS 13 2.00 (0.50, 3.00) 0.00 (0.00, 0.75)

One patient (R77) who showed substantially higher exposures as explained in results was excluded from analysis.

Abbreviations: CI = confidence interval; HSWG = high-sheer wet granulation; max = maximum; min = minimum; N = number of patients; RCD = roller compaction dry-milled; RCS = roller compaction slurry-milled; tmax = time of maximum plasma drug concentration.