TABLE 1.
Mortality in hamsters during the 48 h after administration of a single dose of AMB
AMB dose (mg/kg) | No. of animals that died/total no. of animals tested (%)
|
|||
---|---|---|---|---|
AMB-Doc
|
AMB microspheres
|
|||
Infected | Healthy | Infected | Healthy | |
0 (untreated) | 0/6 (0) | 0/6 (0) | 0/6 (0) | 0/6 (0) |
2.5 | 0/6 (0) | 0/6 (0) | 0/6 (0) | 0/6 (0) |
5 | 6/6 (100) | 0/6 (0) | 0/6 (0) | 0/6 (0) |
10 | 0/6 (0)a | 0/6 (0) | 0/6 (0) | |
20 | 6/6 (100) | 0/6 (0) | 0/6 (0) | |
40 | 0/6 (0) | 0/6 (0) |
All the animals showed uncoordinated movements or abnormal behavior.