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. 2004 Sep;48(9):3246–3252. doi: 10.1128/AAC.48.9.3246-3252.2004

TABLE 1.

Mortality in hamsters during the 48 h after administration of a single dose of AMB

AMB dose (mg/kg) No. of animals that died/total no. of animals tested (%)
AMB-Doc
AMB microspheres
Infected Healthy Infected Healthy
0 (untreated) 0/6 (0) 0/6 (0) 0/6 (0) 0/6 (0)
2.5 0/6 (0) 0/6 (0) 0/6 (0) 0/6 (0)
5 6/6 (100) 0/6 (0) 0/6 (0) 0/6 (0)
10 0/6 (0)a 0/6 (0) 0/6 (0)
20 6/6 (100) 0/6 (0) 0/6 (0)
40 0/6 (0) 0/6 (0)
a

All the animals showed uncoordinated movements or abnormal behavior.