TABLE 2.
Susceptibility of P. falciparum isolated from Kenya to four common antimalarial drugs
| Location (na) | IC50 (ng/ml)b
|
|||
|---|---|---|---|---|
| Chloroquine | Mefloquine | Sulphadoxine | Pyrimethamine | |
| Median (range) | Median (range) | Median (range) | Median (range) | |
| Entosopia (7) | 45 (33-75) | 13 (3-27) | 4,362 (1490-7412) | 200 (99-375) |
| Magadi (7) | 30 (11-71) | 7.4 (0.8-15) | 6,430 (5545-6966) | 333 (41-742) |
| Kericho (5) | 15 (2-31) | 0.8 (0.6-1.0) | 1,070 (705-1650) | 295 (120-473) |
| Kisumu (4) | 12 (1.0-33) | 8.0 (5-9) | 8,429 (7845-9438) | 203 (109-240) |
a
n, number of samples tested.
b
The following IC50s are considered discriminative for resistance; chloroquine, >45.5 ng/ml; quinine, >275 ng/ml; mefloquine, >10 ng/ml; halofantrine, >2ng/ml; pyrimethamine, >15 ng/ml; cycloguanil, >15 ng/ml; sulfadoxine, >10,000 ng/ml; dapsone, >300 ng/ml (18, 24, 43, 47).