TABLE 2.
Pharmacokinetic parameters of moxifloxacin and levofloxacin in serum and lungs of Swiss Webster mice after subcutaneous single-dose administrationa
| Fluoroquinolone | Specimen | Tmax (h)b | Cmax (μg/ml)c | AUC0-24 (μg · h/ml) | Half-life (h) | Elimination rate |
|---|---|---|---|---|---|---|
| Moxifloxacin | Serum | 0.27 | 19.4 | 17.4 | 1.2 | 0.6 |
| Whole-lung homogenate | 0.20 | 0.05 | 0.06 | 1.3 | 0.6 | |
| Levofloxacin | Serum | 0.25 | 25.9 | 25.7 | 0.9 | 0.8 |
| Whole-lung homogenate | 0.63 | 0.06 | 0.06 | 1.2 | 0.6 |
a
Values are calculated from mean concentrations in serum and whole-lung tissue samples taken at 0, 5, 10, 15 and 30 min and at 1, 1.5, 2, 4, and 5 h postinjection. All values are means for at least five or a total of six mice.
b
Tmax, time to maximum concentration of drug in serum and lung.
c
Cmax, maximum concentration of drug observed in serum and lung.