Figure 1.

Study design and schedule of procedures.

Notes: A screening period was followed by study visits on days 1, 2, 9 and 16. Triangles indicate the days on which study end points were assessed (except in the case of physical examinations that were symptom-directed after screening). Plasma samples were collected for amino acid analysis at time 0 minute and at 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, and 180 minutes after administration of the investigational product on days 1 and 2. Plasma for bovine IgG assessment was collected at time 0 minute and 90 minutes after administration of the investigational product on days 1 and 2 and once on day 16. Stool samples for bovine IgG assessments were collected on days 1, 9 and 16. *At least 8-hour fast prior to dosing.

Abbreviation: IgG, immunoglobulin G.