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. 2016 Dec 5;11:6485–6497. doi: 10.2147/IJN.S117184

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© 2016 Wang et al. This work is published and licensed by Dove Medical Press Limited

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In vitro cytotoxicity assay curves for HeLa cells obtained by plotting the cell viability percentage against the concentration of DOX for 24 h (A) or 48 h (B), which was loaded in the DOX@HA-PL-MSNs, DOX@HA-L-MSNs, DOX@L-MSNs, DOX@PL-MSNs, DOX@MSNs, and free DOX solution, respectively.

Note: Data are represented as mean ± SD (n=4; P<0.05).

Abbreviations: DOX, doxorubicin; HA, hyaluronic acid-functionalized; L-MSNs, MSNs coated general lipid-bilayer; MSN, mesoporous silica nanoparticle; PL, pH stimuli-responsive lipid membrane; SD, standard deviation.