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. 2016 Dec 5;12:3083–3092. doi: 10.2147/NDT.S121183

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© 2016 Yao et al. This work is published and licensed by Dove Medical Press Limited

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Downregulated TRAF3 reversed neuronal cell death and attenuated ischemic brain infarction induced by miR-455.

Notes: (A) TRAF3 mRNA level was reduced in neurons treated with sh-TRAF3. t=2.82. (B) The protein level of TRAF3 was reduced in neurons treated with sh-TRAF3. (C) The death rate of neuronal cell treated with sh-TRAF3 was decreased after OGD for 24 hours, t=4.71. (D) miR-455 mimics alone significantly decreased neuronal cell death rate, and sh-TRAF3 strengthened the effect. miR-455 inhibitor increased neuronal cell death rate, whereas sh-TRAF3 rescued neuronal cell death, F=9.27. (E) TRAF3 mRNA level was reduced in brain treated with sh-TRAF3, n=5, t=2.68. (F) TRAF3 protein level was decreased in brain treated with sh-TRAF3, n=5. (G) miR-455 mimics significantly decreased infarction volume after MCAO for 24 hours, and sh-TRAF3 made the effect stronger, n=5, F=5.62. *P<0.05. (H) Effect of TRAF3 on miR-455-mediated infarct volume. Abbreviations: MCAO, middle cerebral artery occlusion; OGD, oxygen–glucose deprivation.