TABLE 5.
Nucleotide and amino acid substitutions in the tet(O) genes of the tetracycline-resistant C. jejuni isolates for which the MIC level is 512 μg/ml
| Nucleotide position | DNA sequence variations in the tet(O) from:
|
Amino acid substitutions in the tet(O) from:
|
||
|---|---|---|---|---|
| GenBank | Highly resistant isolates | GenBank | Highly resistant isolates | |
| 884 | A | G | Y | C |
| 910 | T | C | S | P |
| 993 | A | G | I | M |
| 1036 | A | C | I | L |
| 1063 | T | C | S | P |
| 1111 | T | G | C | G |
| 1772a | C | A | T | N |
| 1784 | A | G | Y | C |
a
Mutation at nucleotide position 1772 is found in all tet(O) sequences in a number of studies, indicating an error in the initial GenBank sequence that has now been corrected (accession number M18896).