Fig.5.

Microglia co-localized with tau oligomers in an aged human tau transgenic mouse model but not in wildtype mouse cortical brain regions. A-C) Minimal microglia Iba1 (red) activation was observed in WT mice. D-F) An increase in activated microglia detected by Iba1 was seen co-localizing with T22 positive tau oligomers (green) in 24-month-old Htau mice. A few examples of microglia co-localizing with T22 positive tau oligomers are indicated by the arrows. G) 24-month-old Htau mice had significantly higher Iba1 compared to WT according to corrected cell fluorescence. ^**p < 0.01. Scale bar 20 μm.