TABLE 3.
Animal | Day | Parameter valuea
|
|||||
---|---|---|---|---|---|---|---|
Half-life (h) | AUC (μM · h) | ClT/F (liters/kg/h) | Cmax (μM) | Vss/F (liters/kg) | Tmax (h) | ||
32325 | 1 | 16.4 | 90.1 | 2.1 | 3.2 | 49.8 | 8 |
14 | 25.3 | 103.7 | 1.8 | 5.7 | 34.5 | 4 | |
32402 | 1 | 10.2 | 60.9 | 3.1 | 5.4 | 45.9 | 2 |
14 | 14.5 | 67.3 | 2.9 | 5.3 | 59.2 | 2 | |
32451 | 1 | 37 | 117.3 | 1.6 | 1.9 | 86.4 | 8 |
14 | 27 | 103.3 | 1.8 | 3.1 | 71.5 | 2 | |
Avg | 1 | 21 ± 14 | 89 ± 28 | 2.3 ± 0.8 | 3.5 ± 1.7 | 61 ± 22 | |
14 | 22 ± 7 | 91 ± 21 | 2.2 ± 0.6 | 4.7 ± 1.4 | 55 ± 19 |
Pharmacokinetic parameters are area under the curve (AUC), systemic clearance (ClT), oral bioavailability (F), peak concentration (Cmax), steady-state volume of distribution (Vss), and time to peak concentration (Tmax).