Table 2.

Logistic regression models showing the association of self-reported pedal edema and left/right ventricular systolic dysfunction (EF <50%) and abnormal NT Pro BNP (>400pg/ml) in MESA

	Univariate Odds Ratio(95% CI)	P value	Multivariable** Odds Ratio(95%CI)	P value
LVSD (LVEF < 50%)	0.61(0.35–1.08)	0.87	0.83(0.45–1.54)	0.57
RVSD (RVEF <50%)*	0.70(0.42–1.19)	0.19	0.67(0.38–1.19)	0.82
Abnormal NT ProBNP( >400 pg/ml)	2.27(1.60–3.20)	<0.001	1.80(1.21–2.68)	0.004
Sleep on > 2 pillows	2.36(1.90 – 2.94)	<0.001	1.66(1.30–2.12)	<0.001
Wake up at night with trouble breathing	2.06(1.67 – 2.53)	<0.001	1.95(1.55 – 2.44)	<0.001

LVSD: left ventricular systolic dysfunction. RVSD*: Only 3501 out of 4196 had RVEF available

^**adjusted for age, gender, race/ethnicity, BMI, systolic BP, diabetes mellitus, cigarette smoking status, serum creatinine levels