TABLE 7.

In vitro endogenous HBV polymerase sensitivity to ETV-TP for patient A

Genotypea	Patient A RT substitution atb:					ETV IC50 (nM)c	Fold increase in IC50d
	I169	V173	L180	M204	M250
wt	—	—	—	—	—	0.5 ± 0.1	1
Baseline (3TCr)	—	L	M	V	—	27 ± 6	54
wk 106	T	L	M	V	V	240 ± 71	480
del 173L	T	—	M	V	V	240 ± 11	480
del 169T	—	L	M	V	V	140 ± 16.4	280
del 250	T	L	M	V	—	26 ± 0.4	52
del 173L, 250V	T	—	M	V	—	32 ± 9.3	64
del 173L, 3TCr	T	—	—	—	V	37 ± 3.7	74

^awt values are for the laboratory genotype D clone pCMV-HBV 180B3. del, deletion.

^b—, wt residue.

^cValues are the mean and standard deviation from three or more independent experiments.

^dFold increase in IC₅₀ over that of the wt control.