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Effects of R126638 and itraconazole on ergosterol synthesis from [14C]acetate
| Organism | Incubation time (h)a | IC50 (nM)b for ergosterol synthesis
|
|
|---|---|---|---|
| R126638 | Itraconazole | ||
| C. albicans | 0 + 24 | 2.2 | 2.8 |
| M. canis | 72 + 24 | 280 | 310 |
| T. mentagrophytes | 32 + 16 | 22 | 82 |
| T. rubrum | 40 + 24 | 33 | 18.5 |
Azoles were added immediately before inoculation; [14C]acetate was added after 0, 72, 32, or 40 h of incubation.
Values are the means of at least three separate experiments.
