TABLE 2.
Recovery of cells and ELF from BAL in healthy adult subjects in the 300-mg-day-dose group (n = 35)
| Value | Result at time point (h)a:
|
||||||
|---|---|---|---|---|---|---|---|
| 2 | 4 | 6 | 8 | 12 | 24 | 48 | |
| Mean (cells/liter) | 1.2 × 108 | 1.4 × 108 | 1.0 × 108 | 1.0 × 108 | 0.7 × 108 | 1.1 × 108 | 0.9 × 108 |
| SD (cells/liter) | 0.6 × 108 | 1.2 × 108 | 0.5 × 108 | 0.4 × 108 | 0.4 × 108 | 0.4 × 108 | 0.4 × 108 |
| PMNs (%) | 1.0 ± 1.2 | 3.6 ± 3.8 | 1.4 ± 0.5 | 1.6 ± 0.9 | 1.6 ± 2.1 | 1.2 ± 0.4 | 1.0 ± 0.0 |
| Lymphocytes (%) | 10.0 ± 10.9 | 12.4 ± 11.8 | 10.8 ± 7.9 | 16.4 ± 11.0 | 9.2 ± 7.6 | 8.4 ± 5.9 | 10.0 ± 8.2 |
| Mono/macro (%) | 69.2 ± 23.3 | 73.0 ± 13.6 | 84.2 ± 7.7 | 74.4 ± 8.3 | 74.0 ± 16.7 | 86.0 ± 10.7 | 85.2 ± 9.8 |
| Eosinophils (%) | 0.4 ± 0.9 | 0.0 ± 0.0 | 0.8 ± 1.1 | 0.2 ± 0.4 | 2.4 ± 4.3 | 0.2 ± 0.4 | 1.6 ± 3.0 |
| Degen cells (%) | 19.4 ± 28.0 | 11.0 ± 9.2 | 2.8 ± 4.1 | 7.4 ± 6.8 | 12.4 ± 15.6 | 4.2 ± 9.4 | 2.2 ± 3.2 |
| ELF volume (ml) | 0.6 ± 0.2 | 0.5 ± 0.1 | 0.9 ± 0.6 | 0.6 ± 0.5 | 0.7 ± 0.1 | 0.5 ± 0.2 | 0.6 ± 0.2 |
a
No significant differences among the groups for cell recovery differential cell count, or volume of ELF (P > 0.05). Comparison testing was not applied to zero values. All data are given as means±SD. Mono/macro, monocytes and macrophages. Degen, degenerated.