TABLE 3.
Cethromycin concentrations in plasma, ELF, and AC at the time of bronchoscopy in the 150-mg-dose group (n = 25)a
| BAL time (h) | Plasma Cmax (μg/ml)b | Plasma concn (μg/ml)c | AC concn (μg/ml)c | ELF concn (μg/ml)c |
|---|---|---|---|---|
| 2 | 0.15 ± 0.08 | 0.12 ± 0.08 | 8.1 ± 4.9 | 0.9 ± 1.0 |
| 4 | 0.19 ± 0.09 | 0.09 ± 0.06 | 9.5 ± 2.5 | 0.9 ± 0.2 |
| 8 | 0.18 ± 0.08 | 0.04 ± 0.02 | 12.7 ± 6.4 | 0.8 ± 0.5 |
| 12 | 0.17 ± 0.08 | 0.02 ± 0.01 | 5.7 ± 4.5 | 0.3 ± 0.3 |
| 24 | 0.20 ± 0.11 | 0.01 ± 0.01 | 2.9 ± 2.4 | 0.1 ± 0.1 |
a
Data are given as means±SD.
b
There were no significant differences among the plasma Cmaxs (P > 0.05).
c
AC concentrations were significantly higher than ELF concentrations at 2, 4, and 8 h (P < 0.05) but not at 12 (P = 0.06) and at 24 h (P = 0.06); ELF concentrations were significantly higher than plasma concentrations at 4 (P = 0.000) and 8 h (P = 0.029) but not at 2 (P > 0.120), 12 (P = 0.059), or 24 h (P = 0.151).